8 Best Estrogen Blockers for Men – 2018 Buying Guide & Top Picks

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By using pregnenolone cream or pregnenolone supplements, the levels of the compound in the body increases, and this brings about various benefits such as fatigue relief, and delay of the aging process.

​Do you associate estrogen with your spouse’s moodiness and crying fits? You’re not in the clear. Estrogen can also affect hormone balance in men. Balancing hormones can be difficult, especially as you age or take supplements. We’ve compiled the best estrogen blocker for men reviews so that you can learn more about what makes up a natural estrogen blocker and how it can help you.

The PES Erase products are some of the strongest you can get without a prescription. Alphadex and Rebirth are also strong natural formulas but are a little more expensive. Inhibit-E, Nature’s Way DIM Plus and AE-3 Chrysin with DIM and Stinging Nettle Root are more gentle formulas. Forma Stanzol V3 is a lotion for those who have trouble taking pills. Pride Nutrition E-Block main ingredient doesn’t have enough scientific research to back it up, although the other ingredients may deliver subtle results.

​Estrogen Blockers Comparison Table





best estrogen blocker Pes-Erase-Pro

Physique Enhancing Science

best estrogen blocker Myokem-Alphadex


  • Brassaiopsis Glomerulata
  • Acacetin
Rebirth PCT

Black Lion Research

  • Ellagic Acid
  • Eucheuma Cottonii

Serious Nutrition Solution

  • Brassaiopsis Glomerulata
  • Broussonetia Papyrifera
  • Indole-3-Carbinol
  • Dehydroabietic Acid

Nature's Way

  • Diindolylmethane

Pure Science

  • Chrysin
  • Diindolylmethane

Muscle Research

  • ChAG (Cyclohexylaminoglutethimide)
  • 7,8 - Benzoflavone

Pride Nutrition

  • Calcium D-Glucarate
  • Chrysin
  • Diindolylmethane


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    The Best Estrogen Blocker Reviews

    Editor Rating

    best estrogen blocker for men PES Erase Pro

    This product comes in two formulations: PES Erase Pro and PES Erase High Affinity Inhibitor. Both help prevent the body from entering a catabolic state as a result of too many stress hormones. They also claim to moderate hormones to optimize your body’s muscle-building capabilities.

    Important Ingredients

    Both PES Erase products contains Androsta-3,5-diene-7,17-dione. This substance is also known as Arimistane. It occurs naturally in the body and is thought to inhibit cortisol and aromatase, therefore lowering estrogen levels. It's chemical name is similar to those of many steroids, but it is not a steroid or prohormone. Read more about Arimistane in our article covering it in detail here.

    PES Erase Pro also contains Pine Bark Extract. Research shows that this natural substance is a therapeutic alternative for the Gn-RHa hormonal therapy often given to sufferers of endometriosis. Because Gn-RHa stops estrogen production, it is thought that pine bark extract may have similar effects. Pine bark extract has also been shown to improve symptoms of erectile dysfunction.

    Things We Liked

    • Fights water retention
    • Tightens muscles

    Things We Didn't Like

    • Can be dehydrating
    • Hard on the joints

    Editor Rating

    Myokem Alphadex

    Myokem Alphadex supports testosterone production by suppressing aromatase and blocking estrogen receptors.

    Important Ingredients

    This product contains a unique proprietary ingredients profile that was created to lower estrogen levels. Brassaiopsis Glomerulata is a estrogen blocker for men​ that can inhibit aromatase. This prevents conversion from testosterone to estrogen. It also contains selective estrogen receptor modulators, also called SERMs. SERMs block the uptake of estrogen at estrogen receptor sites. The safflower seed extract in this estrogen blocker for men has been shown to increase testosterone levels.

    Things We Liked

    • Reduces estrogen through more than one avenue
    • Derived from natural compounds

    Things We Didn't Like

    • Can make you feel dehydrated so increase your fluid intake

    Editor Rating

    Rebirth PCT

    This product is the first natural SERM on the market. It allows estrogen to be created in the body but blocks the receptors for estrogen so that estrogen cannot cause any of it's negative effects. This product is a natural alternative to Clomid which functions in a similar way but with side effects. We are very excited about Rebirth. It's our opinion that the safest and natural way to increase testosterone levels is through the use of natural SERMs. We even dedicated a whole article to this product which you can find here.

    Important Ingredients

    Ellagic acid is a natural compound that suppresses aromatase enzyme that creates estrogen. Evidence also suggests that the Eucheuma Cottonii in the supplement works on similar enzymes. Both are reported to be natural aromatase inhibitors.

    Things We Liked

    • Naturally suppresses the negative effects of estrogen without risk of lowering it too much
    • Works as well as prescription drugs to prevent symptoms of elevated estrogen

    Things We Didn't Like

    • If you already have elevated estrogen, this product will not help in lowering it

    Editor Rating

    Serious Nutrition Solution Inhibit-E Capsules

    This supplement improves testosterone levels naturally by suppressing production of estrogen.

    Important Ingredients

    In addition to Brassaiopsis Glomerulata, this supplement also contains 400 mg of Broussonetia Papyrifera. The isolicoflavanol in this compound is a known aromatase inhibitor. The Indole-3-carbinol in the supplement is a substance that is found in cruciferous vegetables. This compound have been shown to help detox bad estrogens in the body.

    Things We Liked

    • Ingredients are clearly labeled
    • Gentle formula that stimulates natural testosterone production

    Things We Didn't Like

    • Taking too much can cause joint pain if estrogen levels drop too far

    Editor Rating

    Nature's Way DIM-Plus - Estrogen Metabolism Formula

    DIM estrogen blocker is one of the more well-known products in this market. These estrogen pills for men or women are safe for vegetarians and vegans.

    Important Ingredients

    The supplement contains Diindolylmethane (DIM), also found in cruciferous vegetables. DIM helps the body get rid of bad estrogens.

    Things We Liked

    • Works gently and naturally
    • No DIM side effects
    • Natural estrogen blocker

    Things We Didn't Like

    • Did not have extreme results when it came to muscle gain or body fat loss

    Editor Rating

    Chrysin with DIM & Stinging Nettle Root Extract

    This gentle formula is made of natural ingredients and specifically designed to support sexual health in males.

    Important Ingredients

    Chrysin has been linked with increased testosterone. However, research shows that taking it orally has no effect on testosterone levels. The supplement does contain 100 mg of dim Diindolylmethane. Stinging nettle root has a aromatase inhibitor effect that can allow for more free testosterone to circulate throughout the body. It also helps support prostate health.

    Things We Liked

    • No artificial colors
    • Natural ingredients with few side effects
    • Pills are easy to swallow

    Things We Didn't Like

    • Little research to back up efficacy of main ingredient

    Editor Rating

    Forma Stanzol V3 By Muscle Research

    This formula is applied as a lotion. One to two pumps of the product should be applied to the front and back of the abdomen and arms twice a day.

    Important Ingredients

    The ChAG (Cyclohexylaminoglutethimide) in the lotion is a strong aromatase inhibitor. It is important to mention that ChAG is very similar in chemical structure to Cytadren which is a potent anti-steroid drug. Caution should be advised when using this product as it can hence be very potent. We would mostly recommend this product to people who are already on TRT and need to control estrogen and cortisol.  Diindolymethane also helps to detox bad estrogens. Benzoflavone is a potent aromatase inhibitor. Horse chestnut seed extract helps improve circulation, possibly helping with absorption of the product.

    Things We Liked

    • Lotion is potent and  easily absorbed
    • Good option for people who can’t take pills

    Things We Didn't Like

    • Expensive
    • Not a completely natural supplement

    Editor Rating

    Pride Nutrition E-Block Estrogen Inhibitor

    This product is marketed to both men and women to help reduce estrogen and support strength and endurance.

    Important Ingredients

    Calcium D-Glucarate has been shown to decrease estrogen in rats. However, it may also decrease levels of all steroid hormones, including testosterone. Also contains Diindolymethane, Chrysin and Indole-3-Carbinol. There is not convincing scientific evidence to back up the effectivity of Chrysin.

    Things We Liked

    • Made in the U.S.

    Things We Didn't Like

    • Scientific evidence doesn’t back up claims for all ingredients
    • Low amounts of proven ingredients

    natural estrogen blockers for men Feminine Man

    Natural Estrogen Blockers For Men 101

    Imbalanced Estrogen Levels In Men

    Testosterone is considered the quintessential male hormone. It affects almost every cell in a man’s body. More testosterone leads to more “manly” characteristics like increased muscle mass and denser bones. It also helps control mood, blood sugar and heart health.

    As testosterone circulates throughout the body, an enzyme called aromatase turns some of it into estrogen. This estrogen is used to manage sexual health, maintain bones, improve brain function, improve verbal memory and even control HDL levels.

    Testosterone is partly responsible for a high muscle-to-fat ratio. The decrease in testosterone that occurs with age results in more stubborn fat cells existing in the body. These fat cells create more aromatase, which creates more estrogen. This can create a negative cycle, a hormonal imbalance, that increases estrogen and decreases testosterone.

    When Estrogen Is Too High

    Too much estrogen in a man can result in:

    erectile dysfunction impotent

    Taking a testosterone-boosting supplement can also increase your estrogen levels, because there is more free testosterone that aromatase can transform into estrogen. Everyone’s body reacts differently to supplements that affect hormones. You may want to take an estrogen blocker if you experience symptoms of elevated estrogen while taking testosterone boosters.

    An easy way to keep track of your estrogen levels is by doing a blood test:

    For lab tests we highly recommend using MyLabFax as they offer very competitive pricing and a wide array of packages as well as single metric tests.

    It's as easy as:

    • check
      Order the test online.
    • check
      Head to your closest local lab for the test.
    • check
      Results will be available to view online in 3-4 days.

    When Estrogen Is Too Low

    Hormone replacement therapy is often suggested for men with low testosterone and high estrogen levels. Low estrogen levels can result if too much estrogen is blocked. Low estrogen levels in men can also cause health problems, including:

    For people who find it hard to balance their estrogen levels and often find themselves ending up on the lower range, we recommend using SERMs instead of aromatase inhibitors (especially a natural one like Rebirth). This hormone therapy helps in making sure your estrogen levels doesn't go to low as well as protecting you from the effects of high estrogen while simultaneously  maintaining high testosterone levels.

    How to Improve Your Testosterone-To-Estrogen Ratio

    Increased mortality rates have been associated with estrogen levels that are too high or too low.

    Increasing muscle mass increases testosterone. It also boosts your metabolism. This helps prevent fat from building up and creating more estrogen.

    Eating a low-fat diet can reduce estrogen without affecting testosterone levels. However, we are talking about a diet low in bad fats here like trans fats. We recommend people keep healthy fats in their diet like coconut oil, olive oil and avocado etc.

    Having sexual intercourse can increase the testosterone and estrogen ratio. One study that involved giving Cialis to men with erectile dysfunction for 12 months showed that once sexual function was restored, estrogen levels decreased.

    Aromatase inhibitors for men stop testosterone from being converted into estrogen. In the Cialis study, the drug’s aromatase-inhibiting characteristics may also have contributed to lowered estrogen levels.

    When You Need An Estrogen Blocker

    An estrogen blocker can help you regain a balanced testosterone-to-estrogen ratio if you have signs of increased estrogen and low testosterone. Especially if you’ve been gaining weight as you age, estrogen blockers can help you regain lean muscle mass and lose extra pounds.

    chemical structure

    You may have experienced the effect of estrogen had increased if you have been on a steroid cycle. Anabolic steroids can permanently destroy your body’s natural hormonal balance. Estrogen blockers can help reduce some of the negative side effects during and after a steroid cycle.


    We feel like PES Erase Pro is the strongest estrogen blocker contender when it comes to delivering results.

    We also recommend Myokem Alphadex for those who are seeking a unique and more natural ingredient profile.

    Rebirth is the only effective natural SERM and is ideal for people who want to balance their hormones without altering the levels too much. The other products can help manage existing levels of estrogen but won’t significantly lower it.

    The compounds in Forma Stanzol may be highly effective and better used by the body because it is applied topically. However, it contains drug like compounds and is not really a completely natural supplement which is why we only recommend this for people already on TRT.

    Image credits: Amazon.com



    Alex Eriksson (Research Analysis)

    Alex Eriksson is the founder of Anabolic Health, a men’s health blog dedicated to providing honest and research-backed advice for optimal male hormonal health. Anabolic Health aspires to become a trusted resource where men can come and learn how to fix their hormonal problems naturally, without pharmaceuticals.

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