The Complete Guide to Arimistane / Androsta-3 5-diene-7 17-dione

Medically reviewed by — Research analysis by Alex Eriksson

​To lower chronically high estrogen, some men turn to anti-estrogenic foods and pharmaceutical compounds such as Nolvadex and Arimidex. But you’ll be glad to hear, there is something even better you can use: Arimistane, Androst-3 5-diene-7 17-dione

Made available for use as a dietary supplement through ​popular products such as PES Erase and PES Erase Pro, Arimistane is here to stay. However before we dig deeper into what Arimistane is it is crucial that we first discuss estrogen:

Pes Erase Pro

Why does estrogen matter so much? Good question!

If you are a guy, you may have heard how estrogen can cause you big problems. Being predominately a female hormone, estrogen is something some men either have too much of or simply want to keep on the down low. The reason for this is that estrogen can directly affect the amount of testosterone production you have.

For men, there is no hormone more important than testosterone. Testosterone is essentially what makes men manly! Linked directly or indirectly to a host of important bodily functions, all men will benefit from optimizing their testosterone levels.

While testosterone is a naturally occurring substance, for several reasons your levels can fall into decline. Exposure to environmental and nutritional toxins, stress, a poor diet, excess body fat, too little sleep, high blood pressure – all these things and more can cause your testosterone levels to fall.

Low Testosterone Side Effects

The side-effects of lowered testosterone are far-reaching and potentially serious and include:

  • Lowered sex drive
  • Infertility
  • Weight gain
  • Loss of muscle mass or/and muscle building
  • General weakness and fatigue
  • Poor concentration and memory
  • Poor memory (joke!)

Estrogen Up? Testosterone Down!

Androsta-3 5-diene-7 17-dione estrogen structure

Another thing that can lower testosterone is elevated estrogen levels. Where testosterone is the dominant male hormone, estrogen is the dominant female hormone.

While it’s normal for men to have low levels of estrogen – in fact it’s all but essential – too much will drive testosterone levels down and many of the factors that decrease testosterone do so by elevating estrogen.

The opposite is also true; if your testosterone levels fall, estrogen levels will rise.

If you imagine testosterone and estrogen as two things on opposite sides of a set of balancing scales, if estrogen levels go up, testosterone levels go down and vice versa. However, if you can lower your estrogen levels, natural testosterone production will go up and that’s the subject of this article.

Increased estrogen can be a real problem for some men and leads to loss of muscle, excess body fat storage, water retention, mood swings, weight gain, loss of sex drive and basically feeling less-than-manly. It’s fluctuating estrogen levels that make woman moody and gain weight during their periods. This is, of course, something all men want to avoid.

Slightly elevated estrogen levels can usually be addressed easily by eating a diet high in natural anti-estrogenic foods such as cruciferous vegetables or taking a mild anti estrogen supplement such as DIM Plus by Nature’s Way which contains broccoli extracts. It's also important to keep track of what estrogen rich foods you are eating and if they might be impacting your estrogen levels.

Losing weight can help too. However, if you think you have a more serious issue with estrogen, you should get a blood test to confirm:

Natures Way DIM-Plus Diindolylmethane

Arimistane Androsta-3 5-Diene-7 17-Dione – Powerful and Natural Estrogen Blocker

If, after blood and urine tests, you discover your estrogen levels are elevated, there are supplements you can take that will help bring you back to balance and the most effective active ingredient is called Arimistane, also known as Androst 3 5-dien-7 17-dione 3-deoxy-7-oxo-DHEA, 17 dione, and 7 Keto DHEA.

Don’t let those chemical-sounding names put you off though, Arimistane is a naturally occurring substance and is NOT an anabolic steroid or drug. It is, however, a very effective estrogen blocker or, more properly, an potent aromatase inhibitor.


Arimistane is a derivative from DHEA (dehydroepiandrosterone), sometimes associated with the chemical name 3-desoxy 7-keto DHEA. DHEA is a hormone produced by your body's adrenal glands – located on top of your kidneys.

DHEA is a precursor of the hormones testosterone and estrogen. In simple terms, DHEA’s function in the body is to produce adequate amounts and control levels of both of these important hormones.

If DHEA levels should fall, as they tend to do with advancing age, for example, testosterone and estrogen levels can become disrupted. Using a supplement containing Arimistane can help restore proper levels of natural testosterone production and estrogen and thus restore endocrinological balance.

You may not have heard of Arimistane but don’t let that worry you; it’s been researched by the impartial boffins over at and we here at Anabolic Health have successfully used it to reduced very high estrogen levels over 1-2 months’ time; our results confirmed with blood tests. It also is effective at reducing cortisol so can be very effective to lean you out and lose body fat – more on that later.

Aromatase inhibitors prevent excess testosterone converting to estrogen. This is a common if somewhat ironic problem sometimes associated with increased testosterone levels and one that can, thankfully, be avoided.

For example people on TRT (testosterone replacement therapy) can suffer too high estrogen levels from artificially boosting their testosterone too much. Aromatase inhibitors like Arimistane can help with these issues keeping estrogen and testosterone balanced.

Arimistane is the most effective natural aromatase inhibitor on the market today. However if you for some reason want to look at other options there are a few others also available, we covered all the best ones in our roundup article on estrogen blockers. Also check out our featured article on natural SERMs, another way of treating high estrogen levels.

arimistane benefits

Arimistane Benefits

Arimistane has been shown to be a safe and effective supplement for lowering estrogen, increasing testosterone and improving general health and well-being. It works in the same way as pharmacuticals such as Aromasin (Exemestane), but with less side effects. In fact, some studies have revealed that anti estrogen supplements containing Arimistane, such as PES Erase Pro, are the best aromatase enzyme inhibitors available without a pre-existing medical prescription:


Although many Arimistane supplements are aimed at sportsmen and, in particular bodybuilders, that doesn’t mean a man with elevated estrogen levels will not also benefit. Such benefits include:

  • Blocks high levels of estrogen and cortisol
  • Increase in testosterone levels
  • More muscle mass or/and muscle gain
  • Weight loss
  • Boosts libido

Another great benefit of using Arimistane is that it can help you lose fat. This is because estrogen has an affinity for causing increased fat storage – especially around the chest, thighs and butt, and cortisol tends to increase abdominal fat accumulation. Hence, bodybuilders often use Arimistane in cutting protocols to help reduce fat while maintaining muscle mass.

By lowering both estrogen AND cortisol, you get a one-two knockout punch that can help you lose fat fast; great if you are struggling to lean out despite eating right, exercising, weight training and other physical activity.

How Does Arimistane Work?

Arimistane is the closest thing you can get to Arimidex in the supplement world, Arimidex being a popular estrogen blocker used by bodybuilders and also in the treatment of breast and other estrogen-related cancers.

As an aromatase inhibitor, Arimistane lowers estrogen by stopping circulating “free” testosterone being converted to estrogen – something it often does.

By lowering estrogen, your testosterone levels will automatically rise. This also means that available testosterone is better able to do it’s manly job; it’s a win-win situation.

Reducing estrogen will lead to an increase testosterone level no matter what your initial estrogen level is. However, estrogen should not be reduced to boost testosterone if you’re estrogen levels are within normal range. Men need estrogen too, it’s not all bad as many guys think, unless it is present in excess.

Lowering estrogen levels too far can cause unwanted side effects and may lead to serious health implications such as bone loss. If you reduce your estrogen levels too low, you will also kill your sex drive and may suffer from mental issues along with painful joints.

The take home message? Do not use Arimistane capsules or supplements product without confirming that your estrogen levels are excessively high first.

Another interesting fact is that Erase Pro and other similar products containing Arimistane, are suicide inhibitors of estrogen, which means that you do not have to taper down on the dosage at the end of a post-cycle therapy as estrogen will not be rebound.

However, because it is a suicide cortisol inhibitor, it takes longer for estrogen rebound back if you happen to drive it too low so be careful and monitor your estrogen levels during use. Again, do not use these products if your estrogen levels are within or only slightly above normal levels.

Just How Effective Is Arimistane?

Arimistane supplement reviews and research reveal that aromatase inhibitors containing Arimistane such as PES Erase, PES Erase Pro, Olympus Labs ELIM1NATE, and MAN Sports Nolvadren XT are very effective and do exactly what they say they do.

Arimistane is not a new substance but has only gained popularity relatively recently. However, we’re ahead of the curve with cutting-edge information here and we produced an Erase Pro review some months ago – before many people knew of this supplements remarkable properties. Check out our Erase supplement review here along with our reviews of other popular estrogen blockers.

The Best Natural Estrogen Blocking Supplement

From anecdotal reports, Arimistane reviews, and our own strenuous research, we have come to the conclusion that PES Erase Pro is indeed the best Arimistane supplement currently available on the market.

It also contains Pine Bark Extract which further increases testosterone by reducing estrogen production and is a proven fertility test booster.

How to Use

Because PES Erase Pro is so effective, you don’t need to use it for very long and it should generally be used in cycles of four to six weeks.

After successfully completing a post cycle therapy, get your estrogen levels checked and then repeat if you need to take your levels down a little more. Of course, you should always pay attention to the directions on your chosen Arimistane product but, in general, this is the protocol that most of them recommend.


If you have proven elevated estrogen levels, Erase by PES, is the best source of Androsta-3 5-diene-7 17-dione around and it will help lower your prohormones levels within a few short weeks and the compound is so effective that you’ll only need one capsule per day to achieve a noticeable improvement.

Remember though, you still need some estrogen for health and libido so only use such a powerful supplement if you already know your estrogen levels are higher than normal.

You can also find a simple saliva estrogen test here you can do at home if you do not have access to a local lab.

Product Image credits:

Alex Eriksson (Research Analysis)

Alex Eriksson is the founder of Anabolic Health, a men’s health blog dedicated to providing honest and research-backed advice for optimal male hormonal health. Anabolic Health aspires to become a trusted resource where men can come and learn how to fix their hormonal problems naturally, without pharmaceuticals.

Leave a Comment