10 Natural PDE5 Inhibitors: Powerful Natural Alternatives That Work

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By using pregnenolone cream or pregnenolone supplements, the levels of the compound in the body increases, and this brings about various benefits such as fatigue relief, and delay of the aging process.

Having any health condition can take a toll on multiple aspects of a person’s life. It can significantly change a one’s lifestyle and sometimes it can even lower self-esteem. Erectile dysfunction is one such condition and, unfortunately, some people are too embarrassed to seek help from medical professionals for this matter. You do not have to dwell on this medical issue. By using natural PDE5 inhibitors, you can prevent ED from happening.

Natural PDE5 Inhibitors Infographic


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Using natural PDE5 inhibitors gives you an assurance that you are not exposing your body to possible harm caused by commercially produced PDE5 inhibitors such as Viagra.

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PDE5 overview

PDE5 and cGMP in a Nutshell

Phosphodiesterase type 5 (PDE5) is an enzyme that breaks down Cyclic Guanosine Monophosphate (cGMP), which is a substance that relays signals to cells, prompting them to start certain processes.

CGMP’s role in male sexual health is that it helps increase the blood flow by relaxing the smooth muscle tissues and vascular smooth muscles.

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The problem with PDE5 is that it degrades the cGMP in the smooth muscle cells and even in the arterial wall smooth muscle in the lungs. When the blood flow is disrupted, various health problems may occur such as pulmonary hypertension, a condition where the blood vessels are filled with too much fluid. But the most common problem that most males will experience is erectile dysfunction.

To prevent this from happening, the PDE5 or phosphodiesterase type 5 inhibitor was developed. This is used to prevent the actions of PDE5 from breaking down the Cyclic Guanosine Monophosphate. As a result, the blood vessels in the penis and lungs relax and expand, leading to a harder and better erection.

At the moment, there are four types of PDE5 inhibitors used to treat erectile dysfunction. This includes sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), and avanafil (Stendra).


Natural PDE5 Inhibitors to Choose From

Those pharmaceuticals do work, but you have the option to go for a more natural and safer way of treating erectile dysfunction. By going natural, you do not have to worry about taking substances that might harm your body.

Black Ginger Extract

Black Ginger Extract contains polymethoxyflavones that increase the energy level of a person. This is one of the traditional medicines widely used due to its versatility.

A study conducted on mice showed that black ginger has a significant effect on the increase of physical fitness performance and muscular endurance. It can also improve one’s metabolism.

This extract is a medicine for allergies, asthma, gout, diarrhea, dysentery, peptic ulcer, and erectile dysfunction.

01-1_Butea-Superba_alpha mini

Butea Superba

Butea Superba is a tuber vegetable used to boost male vitality. It is commonly used in Thailand as an aphrodisiac.

A 3-month study was conducted on Thai volunteers aging 30 to 70 years old who have erectile dysfunction to test how the preparation of Butea Superba can affect this sexual performance problem. More than 80% of the respondents experienced an improvement.

Icariin Extract

Icariin Extract is a well-known ingredient in the Chinese culture when it comes to natural medicines. It is the main component of horny goatweed, a herbal aphrodisiac commonly used to treat sexual performance problems like erectile dysfunction.

Horny Goat Weed

It is an active flavonol found in the Epimedium plant family. Icariin Extract improves the transmission of Nitric Oxide, a chemical transmitter essential for delivering sufficient blood to the penis tissue. Naturally boosting the transmission of Nitric Oxide will result to a healthy erection.

Aside from acting like testosterone, Icariin Extract can also increase the level of testosterone hormones in your body. Healthy production of testosterone is directly proportional to your sex drive. This means that with the help of this extract, you can enjoy heightened libido.

Testosterone is also responsible for the processes that boost the production of sperm. In addition, it can help keep the prostate healthy.

Providing a solution to your problems on your sexual life is not the only benefit of using Icariin Extract. It can be used to encourage muscle growth, treat problems relating to your bones like arthritis, mitigate mental health issues such as depression, memory loss, and stress.

However, it may take weeks or months for you to notice the results of this extract. But if you are serious in improving your sexual life then this product is worth a try.

Viva Naturals Pycnogenol


Pycnogenol is a product taken from the pine bark of Pinus Pinaster, a tree found in the Mediterranean region. It can also be found in peanut skin and grape seed.

It is commonly used to treat allergies, asthma, high blood pressure, menstrual disorders, and even attention deficit-hyperactivity disorder (ADHD). Heart disorders and blood vessel problems such as stroke, heart disease, and varicose veins are also treated using pycnogenol.

Pinaster is clinically proven to lower cardio-vascular and cholesterol. But aside from these benefits, this product is also a natural PDE5 inhibitor that promotes male fertility by promoting blood flow and significantly improving the sperm morphology.

It can also increase the production of Nitric Oxide so it helps in treating erectile dysfunction.


Forskolin is a compound made from the roots of a plant that belongs to the mint family. It is a common ingredient used in the Ayurvedic medicine, a healing system developed in ancient India.

This is one of the most versatile inhibitors but there are little evidences supporting its benefits.

Nature’s Design Forskolin Extract

The most common advantages of taking forskolin are weight loss, muscle growth, asthma symptoms relief, and increase in testosterone level. It also relaxes the smooth muscles to promote a healthy erection.

A study reported that forskolin helped change the body composition of a group of respondents by decreasing body fat and fat mass. This result was compared to the body composition of another group of respondents who took placebo.

In the same study, there was also an increase of lean body mass in the forskolin group compared to the placebo group.The serum free testosterone level is significantly greater on the first group. However, the change in concentration was insignificant.

NOW Foods L-Arginine Powder


Arginine is slowly gaining popularity due to its heart benefits. It can be found in the food that you eat like fish, grains, nuts, and dairy products. Your body can also produce arginine.

This inhibitor is an amino acid that can change into Nitric Oxide, the neurotransmitter that promotes blood vessel relaxation and dilation. Because of this mechanism, arginine may improve blood flow in the arteries that reduces the likelihood of chest pain, clogged arteries, and coronary artery disease. However, these claims need further research.

Due to the improved blood flow, it can help treat erectile dysfunction. A study conducted on 40 men reported that an intake of arginine together with pycnogenol caused a significant improvement in the sexual function of the respondents.

Artichoke Extract

Artichoke Extract came from the leaves, stem, and roots of the Artichoke plant. This extract contains chemicals that are found in medicines for heart diseases, kidney problems, and anemia.

This herbal medicine can also be used as an antioxidant that protects your liver and helps it regenerate. Digestive and bowel problems can be relieved with artichoke.

Luteolin, the active ingredient in Artichoke, prevents the production of aromatase. Since aromatase converts testosterone to estrogen, it helps maintain the testosterone level.


Quercetin is a flavonoid that can serve as an antioxidant. It fights or reduces free radicals that can cause damage to cell membranes.

Some of the many health problems being treated with the use of Quercetin are allergies, hay fever, and hives. This is achieved by inhibiting histamines. Supplementation of Quercetin relieves hypertension by reducing blood pressure.

Jarrow Formulas Quercetin, Cardiovascular Support

A study reported the potential of Quercetin as a treatment for erectile dysfunction. However, there is no solid evidence to prove this.


Cinnamon is a spice from the bark of tree that is mostly found in Southeast Asia, China, and India. It is used as a medicine for diabetes, bronchitis, cardiovascular diseases and gastrointestinal disorders.

Erectile dysfunction can be psychological in nature; it can be caused by mental illnesses such as stress and anxiety. However, there are times when it is caused by health problems like diabetes and high blood pressure. Since cinnamon helps treat these problems, it can also help prevent erectile dysfunction.


Generally, all of these products are safe to use and are cheaper compared to the synthetic ones. Most of these have been used in traditional medicines hundreds of years ago.

However, one of the downsides of these inhibitors is that while some of the benefits are backed by research, more studies have to be done in order to fully verify and examine its benefits.

Additionally, there is still a need to conduct more tests to ensure that it has no harmful side effects. Another disadvantage is that it may take more time to see the effects of natural PDE5 inhibitors compared to synthetic products.

Alex Eriksson (Research Analysis)

Alex Eriksson is the founder of Anabolic Health, a men’s health blog dedicated to providing honest and research-backed advice for optimal male hormonal health. Anabolic Health aspires to become a trusted resource where men can come and learn how to fix their hormonal problems naturally, without pharmaceuticals.

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