Cordyceps Militaris: VO2max Evidence, the Hirsch and Chen Trials, and Honest Stack Placement

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By using pregnenolone cream or pregnenolone supplements, the levels of the compound in the body increases, and this brings about various benefits such as fatigue relief, and delay of the aging process.

Medically reviewed by Ivan Kokhno, MD — Research analysis by Alex Eriksson · Updated May 2026

Quick answer. Cordyceps militaris is a medicinal mushroom traditionally used in Tibetan and Chinese medicine for vitality, endurance, and sexual function. Modern documented mechanisms include: (1) VO2max and exercise tolerance improvements (multiple human trials show 7–11% improvement in time-to-exhaustion at 1–3 g/day for 3–12 weeks); (2) cordycepin (3'-deoxyadenosine) and adenosine analogues with anti-inflammatory and immunomodulatory properties; (3) possible mild T-supportive effects through Leydig cell stimulation in animal data. Standard daily dose: 1–3 g/day of standardised C. militaris extract (the cultivated form is the same species used in the published trials — you don't need wild Cordyceps sinensis).

The honest framing: Cordyceps militaris has the cleanest performance evidence among medicinal mushrooms. The VO2max data is real, replicated across multiple trials. The T-elevation claims are weaker — mostly animal data. As a respiratory/cardiovascular endurance support, Cordyceps deserves consideration. As a primary T-elevation tool, Tongkat Ali and ashwagandha have stronger evidence. For lifters, the recovery and immune-support angles may matter as much as performance. Below: full mechanism, the trial data, dosing, sourcing, and where Cordyceps fits in a male health stack.

If Super Mario was real, then Cordyceps militaris would be his power-up mushroom.

Seriously. Many people believe this mushroom is the secret hack that fuels Chinese athletes into breaking world records. (Besides vigorous training for decades, of course.)



But does Cordyceps really work? How can you benefit from its power? Is it safe to take?

Let's dig into the matter.



Fresh Cordyceps mushroom

What Is Cordyceps Militaris?

Well, Cordyceps doesn’t really look like the edible mushrooms you see in the grocery store. After all, it's a type of fungi that grows on insect larvae. Kind of brutal, right?

When this fungus infects the larvae, it gradually replaces the insect's tissue. Slender, long stems begin to sprout outwards the doomed bug. Nightmarish stuff.

The remains of both the fungi and the insect are collected, dried, and mixed up. Then, the blend is used to treat kidney disease, fatigue, low sex drive, and other health issues.

By using pregnenolone cream or pregnenolone supplements, the levels of the compound in the body increases, and this brings about various benefits such as fatigue relief, and delay of the aging process.

Now, there’s a growing belief that this parasitic mushroom may just be the key to improving performance—from the gym to the bed!


A Supplement Overview

Although Cordyceps has been used in traditional Chinese medicine for centuries, accessibility remains a problem. That’s why supplement companies have come up with a more viable option, the Cordyceps extract.

Cordyceps extract is now the primary ingredient of many health products on the market, promising everything from general well-being to becoming the super-athlete you’ve always wanted to be.

However, getting the most from this supplement isn’t as simple as grabbing the first bottle you find. It’s necessary to look for something that’s synonymous with quality.

Look for a supplement with 100% Cordyceps mushroom, meaning zero additives like grains, starch, mycelium, or other fillers.

The cultivated and collected mushrooms should undergo hot water extraction to ensure that all the beneficial cordycepin and beta-glucan compounds are extracted. As a pleasant bonus, you'll get all the other nutrients from the mushrooms too.

Sadly, most supplements on the market aren't extracted from 100% Cordyceps mushroom. The main reason is that authentic Cordyceps is difficult to gather and really expensive. In other words, most products out there are just made from myceliated grain. Not terrible, but not fabulous either.

So, whenever possible, opt for a pure Cordyceps product if you want all the potential health benefits.

Which brings us to the exciting part of this whole Cordyceps story.


Perks on Physical Performance

More than 400 types of Cordyceps have been discovered so far, but only two have caught the interest of health research—Cordyceps militaris and Cordyceps sinensis.

For this section, we’re going to focus on just Cordyceps militaris.

So, what are its benefits for physical performance?

Increases VO2 Max

VO2 max is the maximum oxygen consumption rate measured through exercise with increasing intensity. In simple terms, VO2 max is used to determine one's fitness level.

Studies show that the use of Cordyceps supplements helps improve physical performance by increasing VO2 max. However, keep in mind that elite athletes might need a higher dose to get the desired results.

Slows Down Fatigue

In Chinese traditional medicine, healers have long used Cordyceps to treat fatigue and boost physical endurance. Luckily, scientific studies are starting to catch up.

For example, one study published in 2015 reported that Cordyceps may have a positive effect during strenuous exercise by delaying the onset of fatigue. This means a lot to those who are into endurance sports like long-distance running. 

Although we need more clinical trials, this one has established the very potential of Cordyceps militaris, which is a good start already.

Boosts ATP Production

Adenosine triphosphate (ATP) is the primary carrier of energy in all living organisms.

Essentially, an increase in ATP levels means a significant boost in performance since muscle tissues will receive a better supply of energy.

Combine that with a boost in VO2 max and enhanced resistance to fatigue, and the result is an effective formula for optimal physical performance.


Other Benefits to Keep in Mind

Of course, the perks of Cordyceps aren’t limited to physical performance. Here are some other benefits associated with this mushroom and yes, medical studies are discovering even more:

  • Delays Aging

    Most likely, this effect is based on Cordyceps’ antioxidant properties, which have likewise been found to improve sexual function and memory in old mice. Also, mice that received the supplement lived a few months longer than the animals in the placebo group.
  • Slows Down Tumor Growth

    According to studies, this fungus exhibits potential in inhibiting human cancer cell growth such as in the liver, skin, colon, and lungs. Some experts believe the use of Cordyceps mushroom may also reverse the negative effects of anti-cancer treatment.
  • Manages Diabetes

    Cordyceps can reduce blood sugar levels according to several studies on diabetic mice, though this might be due to a special type of sugar that the mushroom contains.

    By the way, the fungus can also reduce risks of kidney disease, which is one of the most common diabetes complications.
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    Protects the Heart

    Cordyceps seems to significantly reduce heart damage caused by poor oxygen supply.

    Researchers attribute this benefit to the mushroom’s adenosine content as well as its ability to decrease bad cholesterol and triglyceride levels—both of which contribute to a higher risk of heart disease.

Cordyceps Militaris cultivation and harvesting using hand

All About Proper Dosage

Most Cordyceps extract supplements come in capsules, which contain the elements of the mushroom in powdered form. As a rule, each capsule comes with about 500 milligrams of the extract.

For men who just want to increase their physical performance, a dosage of 1,000 milligrams per day should be enough. However, elite athletes who want to boost their energy levels even higher may need a larger dose.

Just to be on the safe side though, be sure to talk to your doctor before taking Cordyceps.

Why?

Well, every person is unique. Therefore, it's impossible to predict how someone will react to an exotic natural supplement.

For example, Cordyceps may trigger rare side effects depending on different factors, and your doctor should be aware of that. Last but not least, there’s a minor possibility that Cordyceps could interact with the medications you are taking right now.

Just to be clear, most people tolerate Cordyceps well, with little to no side effects at all. Still, chatting with your doctor is always a wise idea before trying a new supplement.


A New, Promising Option

Cordyceps militaris has been a popular component in traditional Eastern healing doctrines for centuries already. Now, scientific studies report about its effectiveness too. There’s some evidence that Cordyceps could boost physical performance and delay fatigue. The best part? It’s finally available in a more accessible form, the convenient Cordyceps extract.


Where Cordyceps Militaris Fits in a Male Health Stack

Cordyceps is best as an endurance/recovery layer alongside foundational training and the standard hormonal stack. The cleanest practical layering:

  • If using for endurance/cardio: 1–3 g/day standardised C. militaris extract, taken in divided doses with food. Effects on VO2max and exercise tolerance show up at 3–6 weeks of consistent dosing.
  • For immune/recovery support: same dose; additional benefit during high training volume or illness recovery.
  • Substrate / hormonal foundation (stronger T evidence): Tongkat Ali 200–400 mg/day for testosterone substrate.
  • Direct DHT: Butea Superba for downstream signal.
  • Cortisol management: Ashwagandha 600 mg/day KSM-66 (better-evidenced adaptogen than Cordyceps for cortisol/T).
  • Foundational vitamins: Anabolic Octane (D-K-A-E) for vitamin D + K2 + A + E.

The AH Stack-Friendly SKUs

Frequently Asked Questions

Q: Does Cordyceps militaris really improve athletic performance?
A: Yes, modestly. Multiple human trials (Hirsch 2017, Chen 2010 among others) show 1–3 g/day for 3–12 weeks improves VO2max and time-to-exhaustion by 7–11%. Mechanism appears to be improved oxygen utilisation and ATP regeneration via cordycepin and adenosine derivatives. Effect is real but modest; it's not a magic endurance booster.

Q: Cordyceps militaris vs Cordyceps sinensis?
A: C. militaris is the cultivated form used in most modern research and supplements. C. sinensis is wild-harvested from caterpillars in the Tibetan Plateau and is dramatically more expensive ($20,000+/kg). The active compounds (cordycepin, adenosine) are similar in both species; for practical supplementation, cultivated C. militaris is the right choice. Don't pay premium for "sinensis" claims unless you have specific reason.

Q: Does Cordyceps raise testosterone?
A: Animal data is suggestive (mouse Leydig cell studies show stimulation); rigorous human evidence for measurable T elevation is limited. Treat T effects as a possible bonus, not the primary reason to take Cordyceps. The endurance/recovery applications have substantially better evidence.

Q: How much Cordyceps per day?
A: 1–3 g/day of standardised C. militaris extract. The Hirsch 2017 trial used 4 g/day for 3 weeks of high-intensity training; Chen 2010 used 3 g/day for 12 weeks. Higher doses (above 5 g/day) haven't been studied for additional benefit. Take with food; can be taken AM or PM (mild stimulant effect in some users may suggest morning dosing).

Q: Are there side effects to Cordyceps?
A: Generally well-tolerated. Mild GI upset is the most common side effect. Cordyceps mildly stimulates immune function; men with autoimmune conditions should discuss with a prescriber before use. Possible interactions with anticoagulants and immunosuppressants. Avoid in pregnancy/breastfeeding. Buy from reputable manufacturers with third-party testing because the medicinal mushroom market has quality issues.

author

Ivan is a medical doctor that has five years experience in researching and writing health-related content, SaaS companies, startups, motivation and self-growth resources. He also speak five languages. Therefore, he is able to research any topic five times better than the average writer.





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