Dermacrine Review: Everything You Need to Know

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By using pregnenolone cream or pregnenolone supplements, the levels of the compound in the body increases, and this brings about various benefits such as fatigue relief, and delay of the aging process.

Product Name: Dermacrine

Review Date: June 21, 2018

Rating: 3.5 out of 5

Things We Liked

  • check
    Formulation based on sound scientific research
  • check
    Easy to use
  • check
    Counteracts the effects of DHEA supplementation

Things We Didn't Like

  • Long-term use required for effects to be seen
  • Long-term use increases risk for its negative effects
  • Chrysin is proven not to work in current human trials
  • Little information about the brand
  • No information on certifications and manufacturing practices


If you do a quick search for Dermacrine, what you will find is a mix of contradicting and confusing information. This is understandable as the original brand to introduce it went out of business back in 2012.

But, the numerous Dermacrine reviews we’ve seen were raving about its formulation and effects that we just have to check it out for ourselves. This is why we’ve decided to review the product ourselves.

About the Brand

Dermacrine was first introduced to the market by Primordial Performance in 2007. It’s a company based in the United States which focused specifically on the nutritional supplement industry.

This company was closed down in 2012 due to being in high debt. Despite this, Dermacrine was continued by another brand—Body Performance Solutions.

However, the latest brand manufacturing this product goes by the name of Iconic Formulation. The company is relatively new and they also offer other testosterone-boosting creams and topical solutions.

Dermacrine is a topical (transdermal) cream that is used to boost male hormone levels.

By using pregnenolone cream or pregnenolone supplements, the levels of the compound in the body increases, and this brings about various benefits such as fatigue relief, and delay of the aging process.

Main Ingredients


Dehydroepiandrosterone, or DHEA, is a steroid hormone that serves as a prohormone (a precursor) to more commonly utilized androgens such as testosterone and DHT (dihydrotestosterone).

DHEA can be increased by consuming foods that can boost its production and by directly supplementing from external sources. Here are its key benefits to your hormonal health:

  • Increase Insulin-Like Growth Factor (IGF-1)

    IGF-1 is a neurotransmitter that prompts the release of growth hormone (GH). Without it, your workouts would not have those unique muscle building and strengthening effects.

    Long-term DHEA supplementation has been found to increase the body’s IGF-1 levels. This effect is not only beneficial for bodybuilders, but also for older individuals looking to maintain their muscle strength and bone density.


High levels of DHT increases one’s chances of developing androgenic alopecia (hair loss). Fortunately, pregnenolone is among Dermacrine topical’s active ingredients.

Pregnenolone manages DHT’s androgenic properties by getting converted into a manageable level of progesterone. It doesn’t just prevent hair loss though, as it’s also more than capable of improving hair growth.

However, keep in mind that high doses of pregnenolone and progesterone have been found to cause hair shedding. This is independent of any hormonal changes that would have normally caused hair loss.

Anti-Estrogen Complex

Unfortunately, increasing DHEA through supplementation can also increase the estrogen levels in your body. This is due to aromatization that helps keep your testosterone levels in check.

It’s for this reason that Dermacrine contains 7,8-benzoflavone, chrysin, and resveratrol. These are aromatase inhibitors which prevent the conversion of excess testosterone (and androgenichormones) into oestrogen.

This means you won’t have to search for and take an assortment of natural anti-estrogens just to make sure that your sex hormones are kept balanced.

You won’t have to worry as much about estrogen dominance (having too much estrogen in the blood stream) and its effects, such as water retention.

7,8 Benzoflavone

Also known as alpha-napthoflavone, 7,8-benzoflavone is a synthetic aromatase inhibitor that had long been used by those who take exogenous steroids, especially as part of their post-cycle therapy.

Due to its high potency as an aromatase inhibitor, it can boost testosterone without increasing estrogen. It has also been seen to lower cortisol, which in turn prevents muscle mass reduction and increases sleep quality.


Also known as 5,7-dihydroxyflavone, it’s a flavonoid considered to be a natural aromatase inhibitor. In tests done on human cells and tissues, chrysin was observed to prevent estrogen from interacting with its receptors.

However, in human scientific trials, this effect of chrysin is absent. Further research suggests that this is due to the substance not being able to pass through the human cell membrane.


This is a polyphenol commonly found in grapes, particularly on the skin of grapes. It improves natural testosterone levels by preventing aromatization and by boosting natural testosterone production.

Resveratrol can boost your testosterone levels by increasing the steroidogenic acute regulatory protein, or StAR, found in steroid producing cells.

This protein is the one responsible for regulating the rate of steroid hormone production in these cells. By having more StAR, your body is producing testosterone at a faster rate.

Much like when taking other DHEA supplements, after a workout, the body experiences improved muscle repair and growth. High DHEA levels typically have an anabolic effect.

By using pregnenolone cream or pregnenolone supplements, the levels of the compound in the body increases, and this brings about various benefits such as fatigue relief, and delay of the aging process.
Bodybuilding. Man and woman


The primary effect this product aims to provide is to boost your testosterone production and levels. This causes the muscles to increase in strength and endurance.

And since having more lean muscle translates to a faster resting metabolic rate, fat loss can be considered among the product’s effects. Achieving your target body fat could become a bit easier.

Of course, getting a testosterone boost should have a positive effect on your overall sense of well-being—encompassing things such as sexual desire and erectile function.

Despite enjoying these perks, those using it should make sure that they do not use too much. Otherwise, it can cause increased anxiety and greater susceptibility to hair loss.

How to Use

Dermacrine is administered as a lotion every morning after a shower. The amount applied would depend on your weight (refer to the following recommendations):

  • 150 to 190 lbs: 3 pumps
  • 190 to 230 lbs: 4 pumps
  • 230 lbs and above: 5 pumps

The best area to apply the product is on the shoulders and upper back. It’s recommended to avoid washing the area for at least six hours after using it.

dermacrine sustain alpha three bottle stack products

The Verdict

Based on its formulation, Dermacrine can increase total and free testosterone levels while at the same time it prevents the negative effects of DHEA supplementation.

The presence of proven anti-estrogen compounds (resveratrol and 7,8-benzoflavone) prevents the associated estrogen increase from exogenous DHEA intake.

We also found that the bottle puts out the same amount in every pump, which makes it easy to use—this also means that you won’t have to worry about applying too much.

However, due to the new brand carrying Dermacrine, there’s little information available as to the manufacturing practices and ingredient certifications of the product.

Like some Dermacrine reviews we’ve seen, we’ll have to end this with a warning—if you’re competing and have to watch for any banned substances, it’s best to exercise caution and avoid using this topical for the time being.

Product Image credits:

Alex Eriksson (Research Analysis)

Alex Eriksson is the founder of Anabolic Health, a men’s health blog dedicated to providing honest and research-backed advice for optimal male hormonal health. Anabolic Health aspires to become a trusted resource where men can come and learn how to fix their hormonal problems naturally, without pharmaceuticals.

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