5 Best Probiotics for Constipation: Digestive Aids

Medically reviewed by — Research analysis by Alex Eriksson

​Stress? Unhealthy diet? Are you taking or considering Hormone Replacement Therapy (HRT) or Testosterone Replacement Therapy (TRT)? In that case you might want to get the best probiotic for constipation as well.

Constipation is a common issue from stress and living an unhealthy lifestyle, but it can also develop when taking hormone replacements, and probiotics can help you manage those side effect as they improve digestive motility.

You have many options in probiotics and since the discomfort and potential health issues brought by constipation are no laughing matter, you have to ensure that you make the right choice.


A Quick Look at the Best Probiotics for Constipation

Finding the right probiotics for constipation can be daunting, but this summary should help you get started.

​Hyperbiotics PRO-15 Probiotics

This product comes in tiny pearls that are easier to swallow than conventional capsules and provide longer and more effective results from slow release of active probiotics. Constipation is relieved, as well as other digestive issues like gas and bloating.

Earth's Pearl Probiotics

This releases up to 15 times more live CFUs (colony forming units) in the intestines than standard probiotic supplements. CFU is used to measure the amount of viable microorganisms in a sample. These probiotics help symptoms of IBS with constipation, along with other digestive issues.

NOW Foods Probiotics 10

This product provides top quality probiotics at a very affordable price. It contains 10 different strains, including B. lactis that helps in stimulating better peristalsis and relieve constipation.​

Nexabiotic 23 Probiotics

These probiotics are released over a prolonged period for better action in the digestive tract. This feature also helps in maintaining the potency of this probiotic supplement.​

Probonix Liquid Probiotic Drops

The microorganisms are administered in liquid form. This assures better absorption and greater potency of this supplement. It comes with a dropper for measuring the right dosage. One dose is 4 drops (adults) or less (around 1-2 for children).​

The Best Probiotic for Constipation Reviews






Hyperbiotics PRO-15 Probiotics


  • 5 Billion Units (15 Probiotic Strains)
  • 25mg Prebiotic Fructooligosaccharides
Worlds Best Pearl Probiotic & Prebiotic Supplement

Earths Pearl Probiotics

  • 4 Billion Units
    (5  Probiotic Strains)
  • 25mg Prebiotic Fructooligosaccharides
NOW Foods Probiotic

Now Foods

  • 25 Billion Units
    (10 Probiotic Strains)
  • FOS (Fructooligosaccharides)
Nexabiotic 23 Probiotics

Dr. Formulas

  • 34.5 Billion Units
    (23 Probiotic Strains)
Probonix #1 Liquid Probiotic Drops


  • 3 Billion Units
    (12 Probiotic Strains)
  • Natural Grape Flavor

This probiotics for constipation contains 15 targeted strains. This includes various popular strains of Bifidobacterium, Lactobacillus and Streptococcus.

The most commonly used strains for relief of digestive issues like diarrhea and constipation are Bifidobacterium and Lactobacillus.

 Hyperbiotics PRO-15 Probiotics

Hyperbiotics PRO-15 help counter the negative impact of using antibiotics. Constipation and diarrhea can occur, which can be relieved by taking probiotics.

This probiotic comes in a BIO-tract pearl. In this form, the probiotics are slowly released in the intestinal tract for optimum impact. Each pearl is smaller than standard capsules, containing much more CFUs than the traditional capsules.

Things We Liked

  • Easy to swallow pearl
  • Longer shelf life with LiveBac patented manufacturing process
  • Time-release delivery, take only 1 pearl per day

Things We Didn't Like

  • May initially trigger gastrointestinal upset
  • May cause diarrhea during the first use
  • A bit more expensive than conventionally-manufactured probiotics
Worlds Best Pearl Probiotic & Prebiotic Supplement

Key Strains:

  • Lactobacillus acidophilus
  • Lactobacillus reuteri
  • Lactobacillus plantarum
  • Bifidobacterium lactis
  • Bifidobacterium infactis
  • Fructooligosaccharides

Earth's Pearl probiotic also comes in the BioTract technology that delivers 15 times more live cultures into the intestinal tract. It can help in relieving IBS, constipation, diarrhea, and other discomforts in the GI tract.

The pearls are formulated and manufactured to contain the right combination of strains for relief of these symptoms.

These strains also help boost energy and improve mood through enhanced vitamin absorption.

Things We Liked

  • No refrigeration required
  • Lactose-free
  • Non-GMO

Things We Didn't Like

  • Contains other ingredients that may cause issues, such as guar gum and sodium carbonate
  • Coating may come out in the stools
  • May cause stomach bloating

Each capsule contains an exclusive blend of 10 different probiotic strains, which includes:

  • Lactobacillus acidophilus
  • Lactobacillus plantarum
  • Lactobacillus rhamnosus
  • Lactobacillus casei
  • Lactobacillus salivarious
  • Lactobacillus paracasei
  • Bifidobacterium longum
  • Bifidobacterium breve
  • Bifidobacterium bifidum
  • Streptococcus thermophilus
NOW Foods Probiotic

These strains are acid-resistant, ensuring delivery of enough live CFUs to the intestines. This is needed to optimize the health benefits. These strains are also chemically validated, assuring that each capsule does contain these exact probiotics.

Things We Liked

  • Vegan
  • No allergens

Things We Didn't Like

  • Needs refrigeration
  • Dosage needs to be adjusted based on individual response
  • Potency may not be fully assured
Nexabiotic 23 Probiotics

This probiotic comes in an advanced delayed-release capsule. This is a doctor-recommended formulation.

Nexabiotic 23 contains the strains Bifidobacterium infantis and Saccharomyces boulardii. There are also 21 other strains that help improve digestive health.

Things We Liked

  • Comes with revolutionary Lyophilization technology that keeps potency of live microorganisms
  • Room temperature stable
  • Strains used are well-researched

Things We Didn't Like

  • Contains maltodextrin prebiotics, which may be an issue in some sensitive individuals

Probonix is effective in relieving symptoms of constipation, bloating and gas. It can also alleviate seasonal allergies and sinus issues.

Even though the dosage is smaller then other brands, more than 90% of the probiotic population in each dose survives the harsh stomach acids. That means more live microorganisms make it to the intestines where they excert their effects.

Probonix #1 Liquid Probiotic Drops

Probonix do not just help restore the population of the good bacteria in the gut. The strains actively search for toxins and molds in the intestines that can cause digestive problems.

Things We Liked

  • Can be taken with beverages like juice or water
  • No refrigeration needed
  • Easy to administer, just 4 small drops

Things We Didn't Like

  • Flavor is not very likeable
  • Expensive
  • Dropper not accurate for dosing

Things You Must Understand About Probiotic Supplements

There are trillions of probiotics available and each strain gives a different level of health benefit. To get the fastest and most effective relief from constipation, you have to know what specific strains will improve this symptom.

You also have to be aware of what strains are present in a particular product because some probiotics can cause other issues instead of alleviating them.

Can Probiotics Cause Constipation?

People react differently to probiotic treatments. Some may experience immediate relief of symptoms and see improvement in health. Some may suffer from probiotic side effects such as gas and bloating.

Is constipation part of probiotics side effects? According to research, it is not. There aren’t any cultured probiotics known and tested to cause constipation. Medical experts and existing research suggest that other factors contribute to constipation and not directly a result of probiotics use.

What to Look for in Probiotics?

The first thing to look for in choosing the right probiotics products is the presence of live microorganisms. Labels such as “contains live probiotics”, “contains live active cultures” and similar labels are indications of good potency.

It should also contain well-researched strains that target specific health needs such as Bifidobacterium sp. and Lactobacillus sp.

How Long Does It Take for Probiotics to Work?

When results become evident depends on various factors. Some of these are:

Typically, you should be seeing improvement within a week of daily use. If you do not, then maybe the product is not suited for your needs or it has already lost its potency.

Also, there are times when the effects are short-term despite continued use. The relief from symptoms may be evident for a few days or weeks then symptoms return. When this happens, try another formulation or another probiotic supplement.

Probiotic products contain varying levels, blends and strains of probiotics. You should not expect that only one product would give you everything you need.


Considering the features and pros and cons, the best probiotics supplement is Probonix. Its main advantage is its formulation. It comes in liquid form, which is the perfect natural environment for probiotics.

Microorganisms live well in moist environments. Other probiotic products often come in dry capsules, tablets or pearls. The microorganisms are freeze-dried to keep them alive longer. However, in the process, some will die. Some may not even be reactivated once in the digestive tract. In Probonix liquid, the microorganisms are in a natural state, giving them greater chances of survival.

Probonix #1 Liquid Probiotic Drops

Another advantage of Probonix is its microbiotic formulation. The strains actively seek toxins and neutralize these. The strains also seek out pathogenic molds and destroy them. These actions are highly effective in restoring good digestive health and functioning.

Product image credits: Amazon.com

Alex Eriksson (Research Analysis)

Alex Eriksson is the founder of Anabolic Health, a men’s health blog dedicated to providing honest and research-backed advice for optimal male hormonal health. Anabolic Health aspires to become a trusted resource where men can come and learn how to fix their hormonal problems naturally, without pharmaceuticals.

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