L-Arginine Cream: Topical Solutions to Erectile Dysfunction

Given how common erectile dysfunction has become (even among those who’ve just entered their prime), it’s not surprising that countless men are searching for the best L-arginine cream.

Unfortunately, there are currently too many products to choose from, making the entire pursuit quite time-consuming. So, to help you enjoy the benefits of L-arginine faster, we’ve listed five of the best options we found so far.

Best ​L-Arginine Creams Comparison Table





Wick & Ström Advanced Penile Care Formula

​Wick & Ström

  • ​Aqua
  • Ascorbic Acid (Vitamin C)
  • Phenoxyethanol
  • ​Butyrospermum Parkii (Shea) Butter
  • Stearic Acid
  • Glyceryl Stearate SE
  • Glycerin
  • ​L-Arginine
Naturally Complete Arginine Gel

​Naturally Complete

  • ​L-Arginine
  • Aloe Vera Gel Extract Sepigel 305
  • Germall Plus
  • Potassium Sorbate
  • Sorbic Acid
Swanson Arginine Circulation Gel

​Swanson Premium

  • ​L-arginine
  • ​Citric Acid
  • ​Ginseng Extract
Man1 Man Oil Natural Penile Health Cream

​Man1 Health

  • ​Shea Butter
  • ​Tocopherol Acetate (Vitamin E)
  • ​Retinyl Palmitate (Vitamin A)
  • ​Cholcalciferol (Vit. D3)
  • Vitamin C
  • Arginine
  • Carnitine
  • ​Panthenol (Vit. B5)
  • Thiocitic Acid
​Nutrasal Liposomal Magnesium and L-Arginine Cream


  • Magnesium
  • ​L-arginine

A Quick Look at the Best L-Arginine Creams

This one is specially formulated to enhance arousal and sexual performance by correcting poor blood flow in the penis. Aside from providing these L-arginine benefits, it also brings relief from various penile skin conditions.

Naturally Complete’s L-arginine gel helps enhance sexual performance and genital sensitivity. It’s made from non-GMO ingredients, making it a great option for people with sensitive skin.

Much like the other topical solutions here, this gel was specifically developed to improve genital sensitivity and sexual arousal. Additionally, it’s effective in alleviating the symptoms of poor blood circulation.

This cream is packed with vitamins and minerals that work together to improve penile health. It's clinically proven to be safe for sensitive skin. Continuous use promotes penile sensitivity. 

Nutrasal’s offering combines the amino acid L-arginine, magnesium chloride, aloe vera, coconut oil, and beneficial essential oils in one package. Its ingredients are entirely natural and organic.

Reviews of the ​Best L-Arginine Cream

What we like about this product is that it contains shea butter and vitamins C, E, and D3. All of these help resolve common skin concerns like irritation, dryness, redness, and chafing. It’s also light and creamy, meaning it leaves a soft and smooth feel when applied. 

Wick & Ström Advanced Penile Care Formula

Things We Liked

  • check
    Suitable for those with sensitive skin
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    Unscented (no overpowering fragrance)
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    Comes with a money-back guarantee

Things We Didn't Like

  • Lesser L-arginine content compared to other products
  • Limited benefits for those with sexual dysfunction
  • Fails to noticeably improve penile sensitivity
Naturally Complete Arginine Gel

This gel has a noticeable effect on penile blood flow and sensitivity—although there are those who’d surely say otherwise. Well, at least most will agree that having only non-GMO ingredients is a good thing, especially when extracted and combined through cold process technology.

Things We Liked

  • check
    Ingredients undergo cold-processing
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    Made from non-GMO ingredients
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    Odorless and light

Things We Didn't Like

  • May worsen herpes infection
  • Not suitable for men with high blood pressure
  • Inconsistent results for erectile dysfunction

We like that this gel is fast-absorbing and non-greasy, so it doesn’t feel sticky when applied. Also, unlike most other gels here, this one contains ginseng extract and citric acid (antioxidant)—two proven ingredients that are commonly found in erection-enhancing concoctions.  

Swanson Arginine Circulation Gel

Things We Liked

  • check
    Completely odorless
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    From a trusted health brand
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    Numerous positive reviews highlighting potency
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    Can be applied on any area with poor circulation

Things We Didn't Like

  • More expensive than other creams
  • Varying effect on sensitivity
  • Dries a bit too fast
Man1 Man Oil Natural Penile Health Cream

This one has an impressive list of active ingredients, which includes Vitamins A, B5, C, D, and E, as well as L-carnitine and alpha-lipoic acid. Unlike other penile creams though, Man1 Health’s offering has a scent that might be too overpowering for most.

Things We Liked

  • check
    Made in FDA-regulated laboratories
  • check
    Comes with a money-back guarantee
  • check
    Formulated for men with sensitive skin

Things We Didn't Like

  • Pricier than most creams
  • Each bottle only contains four ounces
  • Daily application needed for best results

​Nutrasal’s Liposomal Arginine Cream contains sufficient amounts of magnesium chloride, which should be a good thing considering its benefits to nerve function. We’re also impressed by its all-natural ingredients and lack of artificial preservatives.

​Nutrasal Liposomal Magnesium and L-Arginine Cream

Things We Liked

  • check
    Helps relieve stress
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    Has a detoxifying effect
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    Substitute for non-steroidal anti-inflammatory drugs

Things We Didn't Like

  • Greasy consistency
  • Odd color (yellowish)
  • Scent is a bit off-putting

L-arginine supplements enhance sexual function and help in treating erectile dysfunction.

By using pregnenolone cream or pregnenolone supplements, the levels of the compound in the body increases, and this brings about various benefits such as fatigue relief, and delay of the aging process.

​How Does L-Arginine Improve Erectile Function?

L-arginine, a non-essential amino acid, is transformed by the body into nitric oxide (NO) through the action of the enzyme NO-synthase. Nitric oxide relaxes the blood vessels to enhance penile blood flow and improve erectile potential.

The effect of topical applications can be further improved by taking L-arginine and pycnogenol (pine bark extract) together.

​Are Topicals Better Than Their Oral Counterparts?

Although L-arginine can be taken orally (as a dietary supplement), you’ll find it mostly in the form of gels and creams. However, despite the popularity of these topicals it seems that oral supplements are just as effective.

Also, you need to keep in mind that creams could benefit both you and your partner. When applied directly to the genitals, the amino acid may increase sexual pleasure (somewhat similar to the action of Scream Cream).

​Does L-Arginine Cause Any Side Effects?

Despite sometimes being touted as completely safe, the amino acid can actually trigger side effects. For instance, some people experience headaches and nausea upon using L-arginine. Rarely, it can also trigger skin discoloration and swelling.  

As a rule, experiencing common side effects isn’t dangerous: it's just part of the body’s adjustment to increased amounts of the amino acid. However, if you notice discoloration or swelling, consult with your doctor immediately.

​Also, if you’ve been diagnosed with coronary artery disease or other similar conditions, avoid L-arginine supplementation of any kind. The amino acid has a harmful effect on heart attack survivors that’s yet to be fully understood.

Are There Drug Interactions to Keep in Mind?

L-arginine doesn’t play well with drospirenone, which is commonly found in birth control pills. Together, these two substances may significantly raise blood potassium levels, increasing the risk of kidney failure and other complications. 

Given that you’re planning to use the amino acid topically and that you’re likely to pass on some of it to your partner, it might be best to consult her doctor first about the possible effects of L-arginine.

​Our Recommendation

So, which product would we recommend to those suffering from erectile dysfunction? Well, Swanson’s Arginine Circulation Gel is, in most aspects, superior to the other topicals we highlighted in this review.

Aside from being odorless, it’s also multi-purpose. This means that if you’re having problems with circulation in other parts of your body, you might get relief simply by applying this gel on them.

Of course, we would never say that the product is perfect. After all, it’s the least budget-friendly of the bunch. Also, like most other L-arginine topicals, its effects on sensitivity are a bit inconsistent.

By considering all the pros and cons though, it should still be clear why we chose Swanson’s offering as our favorite L-arginine cream. Try it alongside your testosterone-boosting regimen and you might just put an end to ED.

Image credits: Amazon.com

Alex Eriksson (Research Analysis)

Alex Eriksson is the founder of Anabolic Health, a men’s health blog dedicated to providing honest and research-backed advice for optimal male hormonal health. Anabolic Health aspires to become a trusted resource where men can come and learn how to fix their hormonal problems naturally, without pharmaceuticals.

Ivan Kokhno (Editor)

Ivan is a medical doctor that has five years experience in researching and writing health-related content, SaaS companies, startups, motivation and self-growth resources. He also speak five languages. Therefore, he is able to research any topic five times better than the average writer.

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