Best Cortisol Supplement: Revealing the True Power of Cortisol Supplements

Anabolic Health follows strict standards of editorial integrity to help you make health choices  with confidence. Some of the products we feature are from our partners. Here’s how we make money.

By using pregnenolone cream or pregnenolone supplements, the levels of the compound in the body increases, and this brings about various benefits such as fatigue relief, and delay of the aging process.

​We’re always on the lookout for the best cortisol supplement on the market. Given how high levels of it can wreak havoc on your hormone levels (through adrenal fatigue or adrenal insufficiency), it’s important to always keep it in check.

This is what makes it imperative to supplement with substances that can naturally balance your cortisol levels – something that can serve as a cortisol manager. And, for that, we took a look at some products and here’s the list of the best we’ve tried so far: 

​Best Cortisol Supplements Comparison Table





Natural BioScience Phosphatidylserine

​Natural BioScience (Nugema Research Brands)

  • ​Phosphatidylserine
  • Sunflower Lecithin
  • Phosphatidylcholine (PC)
  • Phosphatidylethanolamine (PE)
  • Phosphatidylinositol (PI)
Havasu Nutrition Ginkgo Biloba + Phosphatidylserine

​Havasu Nutrition

  • ​PURE Ginkgo Biloba
  • Phosphatidylserine
Bulk Supplements Pure Choline DL Bitartrate


  • ​Choline DL-Bitartrate
Organic India Ashwagandha Herbal Supplement


  • ​Organic Ashwagandha root
  • Organic Vegetable Pullulan Capsules
  • Certified Organic Ingredients
Sports Research Suntheanine

​Sports Research

  • ​Suntheanine l-theanine
  • Organic Virgin Coconut Oil
  • Organic Yellow Beeswax
  • ​Softgel Capsule (kosher gelatin, kosher vegetable glycerin, purified water)

A Quick Look at the ​Best Cortisol Supplements

​​This product contains 100 milligrams of phosphatidylserine (PS) in each capsule. It’s free of soy and allergens, as well as contains three forms of PS: phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol.

It combines 120 milligrams of Ginkgo biloba and 100 milligrams of phosphatidylserine in a single capsule. ISO-certified third-party laboratories test the product for potency and content integrity.

​Each serving of this product contain 750 milligrams of Choline with 300 milligrams of it as Choline DL Bitartrate. It’s free of dairy, sugar, soy, gluten, yeast, and additives.

​These are capsules containing USDA-certified organic herbs grown on sustainable land. Each capsule contains 800 milligrams of organic Ashwagandha root, and is kosher and Halal certified.

​It contains 200 milligrams of Sports Research’s patented L-theanine sourced from black and green tea. It contains organic virgin coconut oil and organic beeswax to promote improved l-theanine absorption.

Reviews of the ​Best Cortisol Supplements

​This adrenal fatigue supplement offers great value for money. We’ve liked how it’s just purely phosphatidylserine and there’s nothing else in the product. This makes it convenient to take at any time of the day without disturbing sleep or waking hours.

Natural BioScience Phosphatidylserine

Things We Liked

  • Great value for money
  • Soy-free
  • GMO free
  • ​​Contains different phosphatidylserine form
  • Works with Aderall

Things We Didn't Like

  • Might not be for those looking for more perks
  • ​Body may adjust, diminishing the product’s effect
  • ​Effects seen within two days
Havasu Nutrition Ginkgo Biloba + Phosphatidylserine

​We like that the ingredient combination makes it a convenient supplement for managing elevated cortisol levels. However, with the increased risk of clotting disorder, we don’t recommend it to people with any form of ailment.

Things We Liked

  • ​Made in the U.S.A.
  • ​All-natural ingredients
  • ​​Money-back guarantee from manufacturer
  • ​​Good ingredient combination

Things We Didn't Like

  • ​Some buyers reported having different-colored pills
  • ​Inconsistent product quality
  • ​Might cause migraines
  • ​​Clotting risk (due to Ginkgo)

​We liked that it’s in powdered form as it means we can vary the dosage according to our needs. However, it would be better if it wereL-choline bitartrateand contained inositolfor improved management of the body’s stress response (aka fight-or-flight response).

Bulk Supplements Pure Choline DL Bitartrate

Things We Liked

  • ​​Good value for money
  • ​​Powdered dosage
  • ​Dosage can be varied
  • ​No fillers

Things We Didn't Like

  • ​​No inositol
  • ​​Inferior form of choline
  • ​Might cause loose bowel movement
Organic India Ashwagandha Herbal Supplement

We liked how well it works within minutes of taking it. It doesn’t hurt that the ingredients are all-natural and certified organic, but keep in mind that the main ingredient can make you fall asleep – much like other adaptogenic herbs (including holy basil).

Things We Liked

  • ​​All natural
  • ​​Certified organic
  • ​Lowers blood sugar
  • ​Weight loss (from stress-related weight gain)

Things We Didn't Like

  • ​​Limited to bedtime use
  • ​Can induce lethargy
  • ​​Inconsistent product packaging

This product works wonders – we’ve felt relaxed and those with anxiety were relieved from it. If you’re someone who has ADHD or any anxiety disorder, this is worth looking into.

Sports Research Suntheanine

Things We Liked

  • ​​Patented formula
  • ​Coconut oil content
  • ​No drowsiness
  • ​Improved sleep quality

Things We Didn't Like

  • ​​A bit pricey
  • Overkill for managing stress hormone (cortisol) secretion
  • ​​Not for those witha sensitive stomach

pills with a word help

​How to Choose Cortisol Supplements

​1.    Look for the Right Ingredients

For supplements to control your cortisol levels, they utilize ingredients that keep the steroid hormone in check. Here are a few good examples of ingredients you should look for:

​According to studies, ​Phosphatidylserine (PS) reduces cortisol levels by up to 40%.

By using pregnenolone cream or pregnenolone supplements, the levels of the compound in the body increases, and this brings about various benefits such as fatigue relief, and delay of the aging process.
  • Phosphatidylserine (PS)

    It’s a phospholipid composed of fatty acids and amino acids.

    It does this by purging excess cortisol and protecting nerve cells. This results in reduced stress for your system (especially the adrenal gland), which makes it effective in preventing fatigue or chronic stress.
  • Choline Bitartrate

    It is a nutrient that can be obtained from eggs, dairy, and meat, or synthesized by your body. Deficiency from this nutrient can increase the chances of increased cortisol, prolactin, beta-endorphines, and adrenocorticotropic hormone.
  • Ashwagandha (KSM-66)

    Also known as the Indian ginseng, it’s a herb used to promote healing and relaxation in Ayurvedic medicine. It increases resistance to cortisol’s effects.

    However, not all ashwagandha herbs have this same effect. Only the KSM-66 strain of the herb has the desired effect of lowering cortisol.

​2.    Be Aware of Any Side Effects

​There’s always such a thing as too much, even in taking supplements. Supplements can also induce side effects when taken past certain amounts.

​Be aware of these amounts and compare them with the dosage of the supplement you’re considering for purchase. Even if the dosage is acceptable, you must still keep these side effects in mind as some can be fatal in both the short term and in the long run.

3.    Be Aware of Any Drug Interactions

Chemical substances from food, supplements, and medicine can induce reactions in the body when they interact with certain substances. These interactions can vary, from reducing the effects of medicine to inducing side effects.

For example, phosphatidylserine can decrease the effects of select anti-histamines and increase the effects and side-effects of Alzheimer’s disease medications.

So, when choosing supplements, you have to check for any interactions if you’re taking any medication or when you’re going to take any kind of medication.

​4.    If Possible, Choose Brands with FDA Approval

Supplements do not need to be approved by the FDA. However, when a supplement says it is FDA approved, it means that it has been tested by the agency for safety.

​Unfortunately, FDA approval on supplements doesn’t have anything to do with effectiveness.

​Our Recommended Supplement

​We recommend Natural BioScience Phosphatidylserine for its good value and benefits. It contains only one ingredient which makes dosage control and consumption easier and safer. 

Compared to the other ingredients meant to reduce cortisol, phosphatidylserine has more proven benefits based on actual clinical trials. It also doesn’t keep the stress hormone from serving its key functions (phosphatidylserine simply prevents high cortisol levels even during stressful situations).

Furthermore, various studies have seen its benefits on symptoms of chronic mental ailments and athletic performance. So, you’re not only getting a supplement for controlling cortisol levels but also a supplement for your mental health and physical performance.

​With these in mind, it shouldn’t be surprising that this was our choice as the best cortisol supplement.

Image credits:

Alex Eriksson (Research Analysis)

Alex Eriksson is the founder of Anabolic Health, a men’s health blog dedicated to providing honest and research-backed advice for optimal male hormonal health. Anabolic Health aspires to become a trusted resource where men can come and learn how to fix their hormonal problems naturally, without pharmaceuticals.

Leave a Comment