Laxogenin 5a-Hydroxy Review: Powerful Plant Steroid For Muscle

Medically reviewed by — Research analysis by Alex Eriksson

Gaining muscle and maintaining a lean body can be especially hard for some people. Whether you are a hard gainer having trouble building lean muscle, or an endomorph that seems to gain more fat than muscle mass, there are natural supplements that can help. One is 5a-hydroxy laxogenin. This Laxogenin 5a-Hydroxy review will help you understand what this compound is and how it can help your gains!

5a-hydroxy laxogenin is one of the latest compounds that's making a buzz in the fitness world – and for a good reason. Five alpha hydroxy laxogenin is a plant-based anabolic steroid. It's a powerful aid for boosting performance and especially handy for building muscle mass since it can improve nitrogen retention. What sets this substance apart from other steroids is that it is one of the safest there is. It does not disrupt the body's hormonal balance so it cannot be compared to synthetic and illegal anabolic steroids.

Next we will outline the best laxogenin products available on the market today. If you want to learn more about laxogenin first, skip this and go straight to the next part where we break down its benefits more in detail.

A Quick Look at the Best Laxogenin Supplements


This supplement provides a good amount of laxogenin, along with other muscle-building supportive compounds such as epicatechin. This supplement is all-natural and does not contain any fillers or artificial compounds.

REAL MUSCLE by Modern Man

This 7-in-1 formula is one of the best in its class. It has seven key ingredients along with numerous natural extracts that work together to bring you greater gains. We'll describe it in detail later in this article.

Extreme MUSCLE BUILDER Supplement

This supplement provides one of the largest amounts of laxogenin per serving. This supplement is helpful for those who are trying to lose weight while also gaining mass.

Primeval Labs Super Laxo

One unique thing about this supplement is its liposomal technology, which helps maximize the absorption and use of the beneficial compounds present in the supplement.

STR3NGTH Unleashed with PhytoFUSE Technology

The PhytoFUSE™ technology is helpful in increasing the bioavailability of laxogenin. That means greater absorption and better results within a shorter time frame.

Reviews of the Best Laxogenin Supplements







Team Six Supplements

  • Laxogenin (30mg)
  • Epicatechin
  • DIM
  • KSM-66 Ashwagandha
  • Tongkat Ali
REAL MUSCLE by Modern Man

Modern Man Products

Extreme MUSCLE BUILDER Supplement

muscle growth

  • Laxogenin (50mg)
Primeval Labs Super Laxo

Primeval Labs

  • Laxogenin (120mg)
STR3NGTH Unleashed with PhytoFUSE Technology

Olympus Labs

  • Laxogenin (50mg)

Muscle gains and increased strength could be achieved with this all-natural supplement. The doses are based on clinical studies to provide the following key benefits:

  • Builds lean muscles
  • Improves muscle definition
  • Increases muscle strength

Epicenter also supports testosterone production through the added ingredient Ashwagandha. This product allows you to increase your gains without requiring PCT (post cycle therapy).

This product offers trademarked key ingredients to promote its main benefits, they are:

  • Laxogenin: 30 mg
  • Epicatechin: 150 mg
  • DIM: 150 mg
  • KSM-66 Ashwagandha: 300 mg
  • Tongkat Ali (Longjack): 100mg

This product is pure and natural. It has no fillers, gelatin, added chemicals, dyes and other junk.

Things We Liked

  • Vegetable capsules
  • Does not promote water retention
  • No side effects

Things We Didn't Like

  • Expensive
  • Requires full 30-day dosing for gains to be evident
REAL MUSCLE by Modern Man

This is a 7-in-1 formula. It is designed to promote lean, hard muscle gains. It may help harden up your physique while also increasing muscle strength.

There are many important ingredients in Real Muscle, one of these is ecdysterone. This is a substance similar to Laxogenin, its bioavailable (easy to absorb and ready to use by the cells) and also potent in stimulating protein synthesis. Another ingredient is R-lipoic acid. This component serves as a co-factor for ecdysterone and maximizes nutrient partitioning and increases energy production.

This product contains seven key ingredients that promote lean gains. These include:

  • Epicatechin (50 mg)
  • L-carnitine (500 mg)
  • Creatinine HCL (1 gram)
  • L-cysteine (100 mg)
  • Agmatine sulfate (500 mg)
  • R-lipoic acid (50 mg)
  • Five alpha hydroxy laxogenin acetate (50 mg)

These ingredients help promote better muscle vascularity, increased nitric oxide absorption and retention, as well as improved cellular uptake of nutrients and oxygen.

Things We Liked

  • Many key ingredients in one product
  • Great muscle pump which lasts all day

Things We Didn't Like

  • May cause bloating with initial use
  • May increase appetite

This supplement helps build muscle and improve strength.

Its formulation supports faster muscle building while enhancing muscle recovery from intense training.

Extreme MUSCLE BUILDER Supplement

Its main benefits are:​

  • Increased lean muscle growth
  • Increased strength
  • Extra endurance boost during prolonged training
  • Decreases body fat
  • Improves performance
  • Achieve harder muscles
  • Better recovery

This supplement now has 5a-hydroxy-laxogenin, at 50 mg per serving. It helps balance cortisol response to regulate muscle recovery and catabolism. This compound is also helpful in balancing cortisol levels while on a calorie-restricted diet. It also aids in glucose control and improves thyroid functioning.

Things We Liked

  • May work even better for hard gainers

Things We Didn't Like

  • Effects takes two weeks of use to become apparent
  • Poor bioavailability
Primeval Labs Super Laxo

This supplement is a natural alternative to prohormones. It aids in increasing the rate of protein synthesis. It contains the compound 5a-hydroxy laxogenin which is responsible for this effect.

Super Laxo also has liposomal technology. The active substances are coated with phospholipids to protect them against destructive digestive enzymes in the gut. This greatly helps in increasing the bioavailability of the ingredients.

The main benefits of Super Laxo are:

  • Increased lean muscle mass
  • Supports cortisol regulation
  • Anti-inflammatory effect
  • Faster recovery
  • Improves endurance

Daily recommended dosage is 3-6 tablets, split into 2 separate servings. Each cycle should not last more than eight weeks. Have at least eight weeks off the supplement in between cycles.

Things We Liked

  • No known liver toxicity
  • Does not require liver support or PCT
  • Can be used for 8- to 12-week cycles, with up to 4 weeks in between cycles

Things We Didn't Like

  • Urine may turn smelly
  • Expensive
  • May initially cause some loose stools

This product has been reformulated to provide more power and lean, hard muscles. These capsules contain 50 mg of laxogenin equipped with the PhytoFUSE Technology.

The PhytoFUSE™ technology is a unique delivery system that improves the absorption and bioavailability of 5a hydroxy laxogenin.

STR3NGTH Unleashed with PhytoFUSE Technology

This technology increases absorption and potency up to 6 times compared to other similar products.

Laxogenin forms a complex with certain lipids. This complex allows the blood to deliver the compound to the cells in the most efficient manner. This technology also helps in protecting this important compound from being degraded in the gut before it can reach the target cells.

Key benefits of Str3ngth Unleashed are:​

  • Fuller muscles
  • Increased strength gains
  • Repair joints
  • Control cortisol levels
  • Regulates thyroid function
  • Controls blood sugar

Things We Liked

  • Results may be seen within two weeks of use

Things We Didn't Like

  • Expensive

What Is Laxogenin 5a-Hydroxy?

Laxogenin is a natural plant steroid, classified as a steroidal saponin. It is obtained from the plant Smilax sieboldii. This plant is a relative of asparagus and native to Asia.

Many steroidal saponins belong to the class of plant steroids called brassinosteroids. These are found mainly in the seeds, pollen, and leaves of certain plants. Laxogenin 5a is derived from the rhizomes of S. sieboldii and is considered a brassinosteroid.

Laxogenin functions through a signaling system that influences the receptors on muscle cell surfaces. This particular pathway is called the kinase-mediated signal transduction.​

How Does Laxogenin Work?

At the cellular and tissue level, laxogenin supports increased synthesis of protein. It also helps in slowing protein breakdown. These critical processes assist in building more muscle mass and keeping the gains, preventing muscle breakdown. Especially after intense workouts or while dieting.

Moreover, laxogenin aids in nitrogen retention. This is important in promoting an anabolic environment in the body that supports growth.

Laxogenin is similar in action to Anavar, a popular synthetic anabolic steroid. The difference is that laxogenin is natural and plant-based, making it very safe to use. There is no known laxogenin side effects.

This plant steroid does not affect the natural hormonal balance in the body. It does not affect the levels of hormones such as estrogen and testosterone. This makes it a safe supplement for both men and women who want to easier build lean muscle.

What Are the Benefits of taking Laxogenin?

Studies and user feedback report that laxogenin can help in the following ways:

  • Reduce pain and inflammation, especially in the joints
  • Acts in synergy with other anabolic compounds
  • Serves as an adaptogen, regulating cortisol response
  • Increased ability to build lean muscle mass
  • Promotes faster recovery from injury
  • Reduce LDL (bad) cholesterol

Laxogenin is a beneficial compound in the body. This is particularly useful for those who wish to increase their natural strength and muscle mass. The problem lies in how the body absorbs and uses this compound.

This compound has low bioavailability. That means that it is not readily available for the cells to absorb and use. This is where the formulation of laxogenin-containing supplements become vital. Significant amounts of laxogenin are not going to be of much help if the body cannot use most of it.​


Our top pick is STR3NGTH Unleashed with PhytoFUSE Technology. The supplement incorporates a technology that helps increase the bioavailability of laxogenin. Without this, most of the compound will just be excreted.

STR3NGTH Unleashed with PhytoFUSE Technology
Primeval Labs Super Laxo

We also like Primeval Labs Super Laxo. It has a similar technology for greater laxogenin bioavailability. Aside from that, this supplement in not toxic on the liver, which is paramount.

Liver health is often overlooked. Whatever you take in, whether it's food, drugs or supplements, will eventually affect liver because this organ processes everything in the body.

Aside from these top picks, we also recommend taking other natural means of improving physique and health. There are many natural sources of plant sterol for your health goals.

These supplements in this laxogenin 5a-hydroxy review are not the only ones that can help you. You may also give some attention to your testosterone levels while you are trying to gain lean mass. You may also add certain foods to your diet to increase testosterone levels naturally. This is a hormone that also has a role to play anabolic activity.​

Image credits:

Alex Eriksson (Research Analysis)

Alex Eriksson is the founder of Anabolic Health, a men’s health blog dedicated to providing honest and research-backed advice for optimal male hormonal health. Anabolic Health aspires to become a trusted resource where men can come and learn how to fix their hormonal problems naturally, without pharmaceuticals.

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