Ostarine MK-2866: Best SARM Supplement for Epic Gains

Mihai Voinea
Medically reviewed by Mihai Voinea Doctor of Medicine (M.D.) — Research analysis by Alex Eriksson

​If you want to bulk up and lose fat at the same time, you need to look into the results you can get with Ostarine. Best SARM supplements such as Ostarine MK-2866 could help you get lean gains, all backed by science!

Ostarine mk-2866 best sarm supplement ostarine-compound

What is Ostarine MK-2866?

This compound is also known as enobosarm or MK-2866. It is an SARM or selective androgen receptor modulator developed by GTX. Ostarine was primarily created and studied to prevent osteoporosis and muscle wasting.

Ostarine's main action is promoting a higher degree of nutrient partitioning. This is a huge step towards losing fat and gaining muscle at the same time- a feat believed to be impossible by many people.

How Does Ostarine MK-2866 Work?

MK-2866 supports anabolism but works much better as an anti-catabolic agent. That means it helps in limiting “breakdown” processes. This is very important to optimize for maximum gains.

It binds with receptors on your muscle tissues and stimulates growth. The effect is similar to taking synthetic steroid without any of the side effects.

The difference is that this molecule is not converted into estrogen of dihydrotestosterone(DHT). Estrogen levels increase only very slightly.

These actions make MK-2866 ideal for use during the cutting and the bulking phases.

Significant gains are expected without you having to deal with undesirable water retention and gynecomastia commonly occurring with anabolic steroids.

Weight gain is not as great as other anabolic steroids but gains are cleaner. That means lean muscle gains, with lower weight gains but without the weight from water retention.

Gains from using this SARM supplement last and can be maintained even after you discontinue using the supplement. You must follow proper diet and workout routine, though.

Ostarine MK-2866 and It's Effect on Lean Muscle, Fat, and Metabolism

Calorie deficits are created in order to boost the body’s rate of fat burning. In the process, calorie deficits also put lean muscles at risk for loss. Loss of muscle mass will reduce rate of fat loss. Muscle mass loss is recognized as a potentially dangerous condition for the body. In response, metabolism slows, and so will fat loss.

When you use SARMs such as MK-2866, the lean muscles are protected. This molecule has anti-catabolic actions that keep lean muscles from getting broken down during calorie-deficient states. This will keep metabolic rates high and fat burning at optimum.

Ostarine MK-2866 and Your Tendons, Joints and Ligaments

Ostarine has repeatedly demonstrated its supportive action on healing various types of injuries. It may even help in the prevention of injuries involving the ligaments, bones and tendons.

Studies have demonstrated that this compound is even more effective at injury prevention than testosterone. For this reason, numerous bodybuilders and crossfitters are among the most common purchasers of various SARMs for sale. They take this supplement for recovery of injuries they sustained during training.

When dieting, the tendons, joints and ligaments are also vulnerable. Hard dieting is harsh on the joints, increasing the risk for joint discomfort and problems. This reduces performance during training.

Ostarine protects the joints and strengthens associated tissues like ligaments and tendons. It helps in improving mineral content of the bones and supports collagen synthesis. These actions will allow you to train harder to optimize and keep all lean gains.


Androgenic Effects of Ostarine MK-2866

Ostarine directly affects the androgen receptors in the body. However, it does not convert into DHT and only sligthly convert into estrogen. It may help promote the effects of having high testosterone levels without actually raising the levels of testosterone.

What it does is to stimulate the androgenic receptors involved in building lean muscle. This stimulation also raises metabolic rates and enhances burning of body fat.

MK-2866 jump starts muscle building and fat burning processes without raising testosterone levels.

With a SARM like Ostarine, testosterone levels are not directly affected. Hence, there is minimal effect on estrogen and DHT, resulting in minimal, almost negligible Ostarine side effects.

This is highly desirable. Most people who have tried using synthetic anabolic steroids experience side effects such as enlargement of the breast (gynecomastia), hair loss and water retention. 

Most of these side effects are a result of excess conversion of testosterone into DHT and estrogen. Synthetic anabolic steroids will raise testosterone levels but a lot of the excess will get converted into DHT and estrogen. This raises estrogen levels, resulting in an undesirable inhibitory effect on testosterone levels. It’s a vicious cycle that can end in short-term gains and long-term problems.

It’s basically this formula with synthetic anabolic steroids:

  • Synthetic anabolic steroids --> increased testosterone --> excess converted into estrogen --> too high estrogen and DHT --> = nasty side effects such as gynecomastia, less positive effects from testosterone, water retention, infertility, etc.

Ostarine MK-2366 SARM Side Effects

As previously mentioned, this molecule works similar to anabolic steroids without producing the common side effects related to steroid use. One main reason is that it does not increase estrogen in excess. This hormonal conversion into estrogen is mainly responsible for a lot of anabolic steroid side effects like gynecomastia and reduced testosterone levels. That's why steroids always are combined with estrogen inhibitors such as Arimidex or Arimistane.

Ostarine does not have any inhibiting effect to the HPTA if taken for short cycles of 4 weeks, 25mg per day. It does become slightly inhibiting to the HPTA in higher dosages or with prolonged excess use.

Since this molecule does not get converted much into estrogen. This eliminates the need for on-cycle ancillaries. You do not need to take any anti-estrogen products (AIs) or PCTs. If you do take anti-estrogens, you run the risk of bottoming out estrogen levels in your body. Low estrogen levels is just as problematic as high estrogen levels.

Ostarine is safe on the liver (non-hepatotoxic). You can safely use it for longer cycles compared to most oral steroids.

The cardiovascular system is also vulnerable to negative side effects with anabolic steroid use. Studies on Ostarine revealed minimal, almost insignificant reductions in LDL and HDL cholesterol levels. This means Ostarine has very little impact on the cardiovascular system.

While this supplement is generally safe, it is highly recommended to perform a mini PCT for added precautionary measure. Perform this after an 8-12-week cycle.

Ostarine MK-2866 and PCT

This supplement may be used during PCT or post cycle therapy after steroid use. Keep duration of use and dose properly controlled. Common extended Ostarine cycles last from 8 to 12 weeks, with minimal impact on HPTA. Beginners may buy Ostarine supplements enough for 8 weeks and see how their body responds. If favorable results are obtained, then continue with a longer cycle.

Ostarine Cycles

You can use Ostarine alone when dieting to aid in maintaining muscle mass and strength. Combine this with other PPARs and SARMs and you may get even better results, however, be careful and keep track of your intake and how your body responds.

Ostarine is often used during cutting, a popular combination is with Cardarine (GW-501516). This may boost endurance when performing strenuous cardiovascular exercises.

MK-2866 Ostarine Dosage and Half-Life

Safety and effectiveness are based on proper low dosing. The half-life of Ostarine is 24 hours.

  • Maximum daily dose is 25 mg taken once per day for men
  • Maximum daily dose should not exceed 12.5 mg for women
  • Lowest daily dose for physique improvement in men is 12.5 mg
  • Lowest daily dose for physique improvement in women is 5 mg
  • Therapeutic doses for both men and women is 3 mg
  • Lowest daily dose for therapeutic purposes in men and women is 3 mg
  • Lowest daily dose for tendon and bone benefits is 12.5 mg

The Best Time to Take Ostarine MK-2866

Most SARM reviews, including those for Ostarine highly suggest that the best time to use this supplement is during the cutting or the dieting phase. Its muscle-protecting qualities are highly advantageous because it protects any lean muscle gains from getting lost during calorie-deficient states or intense exercise programs.

Recommended Products

First, we need to address this question: Are SARMs legal? Despite all the benefits and very little negative SARMs side effects, they have yet to receive FDA approval and are considered as doping in many sports.

More studies are still required to ascertain that no aspect of health is possibly threatened with Ostarine. However, if you wish to continue building lean muscles the natural way and don't have to worry about using something that is banned, the next best thing is to buy Epicatechin supplements.

Epicatechin is a naturally occurring compound. One of the most common natural sources is raw cacao nibs and tea. It improves testosterone levels in the body and is very effective in building lean muscle mass since it is an myostatin inhibitor.

Our top pick for epicatechin supplements is Epicenter and we highly recommended it as an replacement for Ostarine until it has FDA approval.


A Ostarine supplement may be an effective product for lean muscle gains. The gains are real, not from water retention. It does not have side effects like most anabolic steroids. Gains are maintained with continued diet and training, even with discontinued use after completing a Ostarine  cycle.

The issue now is with its FDA approval. It has yet to receive the approval in order to make its use and safety official. You may buy SARMs in other forms for your muscle-building needs but Ostarine is at the moment considered a banned and experimental substance.

In the meantime, you may opt to use natural ways to build lean muscles such as using Epicatechin.

Another natural and safe way to increase testosterone levels is taking natural testosterone boosters such as products that contain the following ingredients:

SARMs are effective, as well as other natural muscle builders such as Epicatechin. Safe use is always advised in order to get the optimum Ostarine mk-2866 results. The best SARM supplements can give amazing results with proper use, but for now, stick to supplements that have been established to be safe and effective such as Epicatechin.

Product Image credits: Amazon.com

Alex Eriksson (Research Analysis)

Alex Eriksson is the founder of Anabolic Health, a men’s health blog dedicated to providing honest and research-backed advice for optimal male hormonal health. Anabolic Health aspires to become a trusted resource where men can come and learn how to fix their hormonal problems naturally, without pharmaceuticals.

Mihai Voinea (Editor)

Mihai is a medical doctor and entrepreneur with a burning obsession for performance and health. Mihai is also an IronMan, ultramarathon runner, and co-founder of Marsilian, which owns two e-learning platforms for future medical students and doctors.

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